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Related Experiment Videos

Recurrent acute pancreatitis after isoniazid.

K M Chow1, C C Szeto, C B Leung

  • 1Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. Chow_Kai_Ming@alumni.cuhk.net

The Netherlands Journal of Medicine
|September 16, 2004
PubMed
Summary

Drug-induced acute pancreatitis is a potential complication of tuberculosis treatment. Early recognition and withdrawal of isoniazid can reverse this condition, but permanent avoidance is necessary if suspected or confirmed.

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Area of Science:

  • Internal Medicine
  • Gastroenterology
  • Pharmacology

Background:

  • Acute pancreatitis is a serious condition that requires prompt diagnosis and management.
  • Tuberculosis (TB) treatment, particularly with isoniazid, can rarely lead to drug-induced acute pancreatitis.
  • Differential diagnosis of acute abdomen should include drug-induced pancreatitis in patients starting TB treatment.

Observation:

  • A case of acute pancreatitis occurred shortly after initiating isoniazid for genitourinary tuberculosis.
  • The pancreatitis resolved upon discontinuation of isoniazid.
  • The patient experienced a recurrence of pancreatitis 12 years later when isoniazid was restarted for pulmonary tuberculosis.

Findings:

  • Isoniazid is a potential cause of drug-induced acute pancreatitis.

Related Experiment Videos

  • Pancreatitis induced by isoniazid can be reversible with early drug withdrawal.
  • Re-challenge with isoniazid led to recurrent pancreatitis, confirming the drug's role.

    • Implications:

    • Clinicians should consider isoniazid-induced pancreatitis in patients presenting with acute abdomen during TB therapy.
    • Prompt recognition and drug cessation are crucial for managing isoniazid-induced pancreatitis.
    • Confirmed or highly suspected isoniazid-induced pancreatitis necessitates permanent avoidance of the drug to prevent recurrence.