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Disaccharide analysis of the skin glycosaminoglycans in systemic sclerosis
S Akimoto1, H Hayashi, H Ishikawa
1Department of Dermatology, School of Medicine, Gunma University, Maebashi, Japan.
The British Journal of Dermatology
|January 1, 1992
Abstract:
The disaccharides constituting chondroitinase-digestible glycosaminoglycan (GAG) in the skin lesions of patients with systemic sclerosis were determined using high-performance liquid chromatography (HPLC). In scleroderma there was an increase in the amount of delta Di-4S(DS), the main disaccharide unit of dermatan sulphate, and a decrease in delta Di-HA, the disaccharide unit of hyaluronic acid, as compared with normal skin from a similar site. The distribution pattern of the main disaccharides constituting chondroitin sulphate and dermatan sulphate in scleroderma differed from that in scars or scleredema.