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Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications: An in vivo evaluation.

R van Dijkhuizen-Radersma1, J R Roosma, J Sohier

  • 1OctoPlus Technologies B.V., Zernikedreef 12, 2333 CL, Leiden, The Netherlands. vandijkhuizen@octoplus.nl

Journal of Biomedical Materials Research. Part A
|September 16, 2004
PubMed
Summary

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Poly(ether-ester)s degraded faster in vivo than in vitro, with aliphatic succinate segments accelerating breakdown. These biocompatible polymers showed inflammatory cell involvement and phagocytosis during degradation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Multiblock poly(ether-ester)s are potential biomaterials.
  • In vitro degradation and biocompatibility data were previously reported.
  • In vivo evaluation is crucial for understanding real-world performance.

Purpose of the Study:

  • To evaluate in vivo degradation and biocompatibility of poly(ether-ester)s.
  • To correlate in vivo findings with prior in vitro results.
  • To investigate the impact of chemical composition on degradation.

Main Methods:

  • Subcutaneous implantation of porous polymer sheets in rats for 32 weeks.
  • Monitoring degradation via histology, gel permeation chromatography (GPC), and nuclear magnetic resonance (NMR).

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  • Assessing biocompatibility through in vitro cytotoxicity and in vivo histological analysis.

    • Main Results:

    • Substitution of terephthalate with succinate units accelerated degradation.
    • In vivo degradation showed a faster initial molecular weight decrease compared to in vitro.
    • Oxidation, hydrolysis, and phagocytosis by macrophages were observed in vivo.
    • Oligomer solubility in extracellular fluid was higher than in phosphate buffer.
    • Polymer fragmentation and minor composition changes occurred over time.

    Conclusions:

    • Poly(ether-ester)s exhibit biocompatibility, confirmed by both in vitro and in vivo studies.
    • In vivo degradation is influenced by hydrolysis, oxidation, and biological interactions.
    • Aliphatic succinate segments enhance degradation rates.
    • In vivo and in vitro degradation results show good correlation, with some differences attributed to the biological environment.