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Updated: May 23, 2026
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Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
Published on: June 27, 2013
[Atomic force microscopy: from cell imaging to molecular manipulation].
Pierre-Emmanuel Milhiet1, Patrice Dosset, Marie-Cécile Giocondi
1Centre de Biochimie Structurale, UMR 5048 CNRS, UMR554 INSERM, Université Montpellier I, 29, rue de Navacelles, 34090 Montpellier Cedex, France. pem@cbs.cnrs.fr
Journal De La Societe De Biologie
|September 17, 2004
Summary
Atomic force microscopy (AFM) enables high-resolution imaging and manipulation of biological samples in solution. This review highlights AFM
Area of Science:
- Biophysics
- Surface Science
- Nanotechnology
Context:
- Biological samples are complex and require high-resolution imaging techniques.
- Understanding molecular interactions and cellular structures is crucial in biology.
Purpose:
- To review the capabilities of atomic force microscopy (AFM) for biological applications.
- To showcase recent advancements and diverse applications of AFM in life sciences.
Summary:
- Atomic force microscopy (AFM) provides nanometer to angstrom resolution for imaging biological surfaces in physiological solutions.
- The review covers AFM's use in observing intact cells, membranes, and single molecules.
- It also details AFM's role as a nanotool for manipulating biomolecules and measuring molecular forces.
Impact:
- AFM offers unprecedented insights into the structure and mechanics of biological systems at the molecular level.
- This technology facilitates advancements in drug discovery, biomaterials, and fundamental biological research.
