Related Experiment Video
Updated: Aug 22, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
Published on: February 5, 2018
[Over-the-counter drugs in the inquiries to the Poison Information Centre]
1Toxikologické informacní stredisko, Klinika nemocí z povolání 1. lékarské fakulty Univerzity Karlovy, Praha. mkren@lf1.cuni.cz
Abstract:
The aim of the study is to assess the occurrence of inquiries to the Poison Information Centre in the years 1998-2002, concerning medical preparations containing active agents included in Act No. 79/1997 on Drugs in the group of over-the-counter (OTC) drugs which can be sold in the Czech Republic in other shops than pharmacies. It deals especially with medical preparations containing paracetamol, ibuprofen, mephenhydramine teoclate, disinfectants with iodine or 10% solutions of quaternary ammonium compounds and 3% solutions of hydrogen peroxide. The attention is focused on the quantitative assessment of inquiries, sex, age of patients, ingested dose, way of intoxication, recommended treatment and prognosis of the intoxication of the patient. The computer programme employed was established for the registrations of the calls to the Poison Information Centre. The highest number of intoxications was seen in the case of pharmaceuticals containing paracetamol and ibuprofen. The inquiries on OTC drugs that can be sold in other shops than pharmacies represent 6.3% of all calls during this five year period. The intoxication in women, suicidal attempts, ingestion of a toxic dose, rather good prognosis and a combination of several drugs predominate in the calls.
More Related Videos
Related Concept Videos
Pharmaceutical Poisoning: Potential Scenarios
Pharmaceutical Poisoning: Treatment Strategies
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Prevention of Further Absorption of Poison
Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...

