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A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

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Implementation and evaluation of a two-compartment model for quantification of myocardial perfusion with rubidium-82

P Herrero¹, J Markham, M E Shelton

¹Cardiovascular Division, Washington University, St. Louis, MO 63110.

Circulation Research

|March 1, 1992

Summary

Quantifying myocardial perfusion with Rubidium-82 (82Rb) positron emission tomography is feasible using a two-compartment model. This method accurately estimates blood flow and shows potential for assessing myocardial viability.

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Area of Science:

Cardiovascular Imaging
Nuclear Cardiology
Physiology

Background:

Positron emission tomography (PET) allows noninvasive assessment of myocardial perfusion.
Accurate quantification of regional myocardial blood flow (MBF) using generator-produced Rubidium-82 (82Rb) has been challenging due to tracer behavior.
A validated kinetic model is needed for precise 82Rb PET perfusion quantification.

Purpose of the Study:

To evaluate the efficacy of a two-compartment kinetic model for quantitative assessment of regional myocardial blood flow using 82Rb PET.
To determine if 82Rb PET can accurately estimate myocardial perfusion in absolute terms (mL/g/min).
To explore the potential of kinetic parameters as indicators of myocardial viability.

Main Methods:

Dynamic 82Rb PET scans were performed in 13 dogs under various physiological conditions (rest, hyperemia, ischemia, reperfusion).
A two-compartment kinetic model was applied, fixing the distribution volume and tomographic parameters.
Regional myocardial blood flow was calculated and compared with measurements obtained using radiolabeled microspheres.

Main Results:

Estimates of regional myocardial blood flow using 82Rb PET correlated well with microsphere measurements (r=0.91, p<0.05) across a wide flow range (0.14-4.25 mL/g/min).
The kinetic parameter k2, a measure of tracer backflow, significantly increased in regions with severe ischemia, suggesting a potential index of viability.
The two-compartment model provided physiologically meaningful estimates of myocardial perfusion.

Conclusions:

Quantitative assessment of regional myocardial perfusion using 82Rb PET is achievable with a physiologically appropriate two-compartment kinetic model.
This approach enables accurate blood flow quantification in clinical settings utilizing 82Rb.
The kinetic parameters derived from the model may offer insights into myocardial viability and tissue characteristics.