Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Restless legs in Tourette syndrome.

P Lespérance1, N Djerroud, A Diaz Anzaldua

  • 1Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.

Movement Disorders : Official Journal of the Movement Disorder Society
|September 17, 2004
PubMed
Summary

Restless legs syndrome (RLS) and Tourette's syndrome (TS) share sensory-motor features. This study found RLS in 10% of TS patients and 23% of parents, with a maternal RLS link suggesting a genetic influence on TS expression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posttranslational modifications & lithium's therapeutic effect-Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders.

Neuroscience and biobehavioral reviews·2021
Same author

Alpha galactosidase A activity in Parkinson's disease.

Neurobiology of disease·2018
Same author

Catatonia with schizophrenia: From ECT to rTMS.

L'Encephale·2017
Same author

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.

Molecular psychiatry·2017
Same author

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Translational psychiatry·2017
Same author

Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.

Molecular psychiatry·2017

Area of Science:

  • Neuroscience
  • Genetics
  • Clinical Neurology

Background:

  • Restless legs syndrome (RLS) and Tourette's syndrome (TS) exhibit overlapping phenomenological features, specifically sensations alleviated by movement.
  • Despite shared characteristics, the relationship and potential comorbidities between RLS and TS remain underexplored in scientific literature.

Purpose of the Study:

  • To investigate the prevalence of RLS in individuals diagnosed with Tourette's syndrome (TS) or chronic tics.
  • To examine the association between RLS in probands and RLS in their parents, exploring potential familial or genetic links.
  • To identify comorbidities associated with RLS within a cohort of TS probands and their families.

Main Methods:

  • A cohort of 144 probands diagnosed with TS or chronic tics was recruited for the study.

Related Experiment Videos

  • Family history, including the presence of RLS, was collected from both probands and their parents.
  • Statistical analysis was performed to determine the prevalence of RLS and its correlation with parental RLS and TS diagnosis.

    • Main Results:

    • Restless legs syndrome (RLS) was identified in 10% of the probands with Tourette's syndrome (TS).
    • A higher prevalence of RLS was observed in the parents of probands, with 23% reporting the condition.
    • A significant association was found between RLS in probands and the presence of RLS in their mothers, but not fathers.

    Conclusions:

    • The findings suggest a potential maternal factor contributing to the expression of Tourette's syndrome (TS), possibly linked to Restless Legs Syndrome (RLS).
    • The study highlights the importance of considering RLS as a comorbidity in TS and exploring familial patterns.
    • Further research is warranted to elucidate the specific genetic or environmental mechanisms underlying the RLS-TS association.