[Changes in lipid peroxidation in psoriasis].

Area of Science:

• Biochemistry
• Dermatology
• Oxidative Stress Research

Context:

• Psoriasis is a chronic inflammatory skin condition.
• Lipid peroxidation (LP) involves cellular damage from free radicals.
• Understanding LP in psoriasis is crucial for treatment strategies.

Purpose:

• To investigate changes in lipid peroxidation processes in the skin and blood of psoriasis patients.
• To compare LP markers during active psoriasis and remission stages.
• To analyze correlations between LP markers in skin and blood.

Summary:

• Patients with progressing and remitting psoriasis showed decreased levels of diene conjugates, ketodienes, and conjugate trienes in skin lipids compared to controls.
• Thiobarbituric acid (TBA) tests revealed lower TBA-positive products in affected and unaffected skin.
• Blood LP indices remained significantly higher than controls during exacerbation and did not normalize after lesion elimination.
• LP marker levels in remission did not reach control figures.
• Correlations were found between blood and skin LP parameters, varying with disease stage.

Impact:

• This study highlights persistent oxidative stress in psoriasis, even when skin lesions are not active.
• Findings suggest LP markers could serve as indicators of disease activity and progression.
• Results may inform the development of targeted therapies addressing oxidative damage in psoriasis.