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Updated: Aug 22, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
Published on: April 25, 2025
[Medical management of post-obstruction diuresis syndromes]
Emmanuel Van Glabeke1, Gérard Corsia, Xavier Belenfant
1Service de Chirurgie Viscérale et Urologique, CHI André Grégoire, Montreuil, France. emmanuel.van-glabeke@chi-andre-gregoire.fr
Abstract:
The presence of urinary tract obstruction affects the proximal urinary tract by altering renal filtration and excretion functions, resulting in accumulation of electrolytes. Many pathophysiological mechanisms are also involved during obstruction and may be expressed secondarily. For example, relief of obstruction, which restores free flow of urine, is accompanied by marked diuresis and electrolyte disorders. The post-obstruction diuresis syndrome can lead to dehydration, or even shock and acute renal failure. Strict and specialized monitoring is required during the post-obstruction phase. Medical management is designed to avoid serious haemodynamic and metabolic disorders.
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