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Age-related changes in the visual cortex: a review.

C Polidori1, Y C Zeng, D Zaccheo

  • 1Sezione di Anatomia Umana, Istituto di Farmacologia, Università di Camerino, Via Scalzino 5, 62032 Camerino, Italy.

Archives of Gerontology and Geriatrics
|November 1, 1993
PubMed
Summary

Aging significantly impacts the visual cortex, causing anatomical, biochemical, and functional declines. This review details age-related changes in the occipital cortex, affecting vision in the elderly.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Ophthalmology

Background:

  • The visual cortex is crucial for visual function.
  • Aging induces significant alterations in the brain.
  • Specific changes in the aging visual cortex are not fully understood.

Purpose of the Study:

  • To review age-related anatomical, biochemical, and functional changes in the visual cortex.
  • To highlight the impact of aging on visual processing.
  • To emphasize the need for further analysis of the aging visual cortex.

Main Methods:

  • Literature review of studies on aging and the visual cortex.
  • Analysis of morphological, biochemical, and functional changes.
  • Synthesis of findings on occipital cortex (areas 17-19) alterations.

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Main Results:

  • The aging visual cortex exhibits nerve cell loss, particularly in later life.
  • Cholinergic, serotonergic, and GABAergic neurotransmissions are notably affected.
  • Functional declines in elderly visual cortex activity are documented.

Conclusions:

  • Aging leads to significant structural and functional deterioration of the visual cortex.
  • Neurotransmitter systems are particularly vulnerable to age-related changes.
  • Further research is essential to understand and potentially mitigate the effects of aging on visual function.