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Updated: Aug 24, 2026

Robotic Production of Cancer Cell Spheroids with an Aqueous Two-phase System for Drug Testing
Published on: April 23, 2015
Best practices to master robotic preparation of ready-to-administer systemic anticancer therapy in hospital
M Crul1, C Polidori2, D Paolucci3
1Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Center, location Vrije Universiteit, Amsterdam, The Netherlands.
Abstract:
Automated reconstitution or preparation of systemic anticancer therapy has gained traction in the past decade. Transitioning from traditional manual workflows to fully automated production offers multiple benefits: decreased pharmacy staff workload, reduced risk of repetitive strain injuries, minimized medication errors, and lower risk of occupational exposure to hazardous medicinal products, especially when the robotic preparation areas are fully enclosed. Several elements can facilitate efficient implementation and improve productivity and safety in the use of robotic systems. The purpose of this study was to aggregate insights from an international expert group of early adopters on optimizing both productivity and safety in robotic drug preparation. Eight best practices regarding workflow, quality management, software integration, cleaning protocols, staff training, and safety measures during drug shortages have been identified and agreed upon. Application of these recommendations will enhance the robotic system efficiency, accelerate product turnaround times, and improve oncology pharmacy services.
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