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Updated: Aug 22, 2026

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Published on: June 20, 2018
Spontaneous regression of recurrent squamous cell carcinoma of the tongue
1Department of Oral and Maxillofacial Surgery, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Fukuoka, Japan. r-oya@clnc.uoeh-u.ac.jp
Abstract:
A 73-year-old man presented with well-differentiated squamous cell carcinoma of the tongue (T3N0N0). After the completion of external beam radiotherapy (32 Gy) and oral tegafur-uracil (UFT) administration, the tumor had clinically disappeared. Two years later, a recurrent lesion was confirmed histologically. Without any specific therapy, the tumor gradually and spontaneously regressed, from 4 months after the recurrence was diagnosed, and it had completely disappeared both clinically and by computed tomography imaging at 1 year and 4 months after recurrence. There was no evidence suggesting regrowth of the disease in the patient at 3 years and 7 months after the histological confirmation of tumor recurrence.
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