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[Experimental study of Ginkgo biloba exocarp polysaccharides on HL-60 cells in vitro]
Aihua Xu1, Huasheng Chen, Buchan Sun
1Medical College of Yangzhou University, Yangzhou 225001.
Objective:
To study the effect of Ginkgo biloba exocarp polysaccharides (GBEP) on HL-60 cells in vitro.
Method:
Cell culture, MTT, flow cytometry were performed to observe proliferation, apoptosis and changes of relevant gene expression of HL-60 cells.
Result:
GBEP (40-160 mg/L, 48 h) could inhibit HL-60 cells proliferation and the expression of proliferation-promotion gene c-myc, induce HL-60 cells apoptosis and down-regulate the expression of apoptosis-inhibitory gene bcl-2.
Conclusion:
Influence of GBEP on HL-60 cells proliferation and apoptosis may relate to its effects on the expression of proliferation-promotion gene c-myc and apoptosis-inhibitory gene bcl-2.
