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Updated: Aug 22, 2026

Computational Modeling of Retinal Neurons for Visual Prosthesis Research - Fundamental Approaches
Published on: June 21, 2022
Adaptive learning algorithms for nernst potential and I-V curves in nerve cell membrane ion channels modeled as
Vikram Krishnamurthy1, Shin-Ho Chung
1Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada. vikramk@ece.ubc.ca
Abstract:
We present discrete stochastic optimization algorithms that adaptively learn the Nernst potential in membrane ion channels. The proposed algorithms dynamically control both the ion channel experiment and the resulting hidden Markov model signal processor and can adapt to time-varying behavior of ion channels. One of the most important properties of the proposed algorithms is their self-learning capability--they spend most of the computational effort at the global optimizer (Nernst potential). Numerical examples illustrate the performance of the algorithms on computer-generated synthetic data.
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