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Related Experiment Videos

Regulatory evolution across the protein interaction network.

Bernardo Lemos1, Colin D Meiklejohn, Daniel L Hartl

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. blemos@oeb.harvard.edu <blemos@oeb.harvard.edu>

Nature Genetics
|September 21, 2004
PubMed
Summary
This summary is machine-generated.

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Protein interactions limit evolutionary changes in gene expression. Interacting proteins show similar expression variation and evolutionary dynamics across species like yeast and fruit flies.

Area of Science:

  • Evolutionary biology
  • Molecular biology
  • Genetics

Background:

  • Protein-protein interactions are fundamental to cellular functions.
  • Understanding the evolutionary constraints on gene expression is crucial.

Purpose of the Study:

  • To investigate the relationship between protein-protein interactions and evolutionary variation in gene expression.
  • To determine if interacting proteins exhibit correlated evolutionary dynamics.

Main Methods:

  • Analysis of gene expression variation data across different strains.
  • Examination of protein-protein interaction networks.
  • Comparative analysis in model organisms (budding yeast and fruit flies).

Main Results:

Related Experiment Videos

  • Protein-protein interactions are negatively associated with evolutionary variation in gene expression.
  • Interacting proteins display similar levels of expression variation.
  • Expression levels of interacting proteins are positively correlated across strains.
  • These patterns are conserved in diverse eukaryotes.

    • Conclusions:

    • Interacting proteins experience coupled evolutionary trajectories.
    • Gene expression evolution is constrained by protein interaction networks.
    • Protein complex stability may drive coordinated expression evolution.