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Updated: Aug 22, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
[Synthesis and antioxiactivity of squamosamide cyclic analogs]
Ping Xie1, Xiao-zhen Jiao, Xiao-tian Liang
1Department of Drug Synthesis, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China. pingxie123@vip.sohu.net
Objective:
To design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.
Methods:
Eleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.
Results:
Eleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.
Conclusion:
Cyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.
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