Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antifolates -- past, present and future.

Aleem Gangjee1, Hiteshkumar D Jain

  • 1Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA. gangjee@duq.edu

Current Medicinal Chemistry. Anti-Cancer Agents
|September 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determination of the pyrrolo[2,3-d] pyrimidine antifolate AGF94 from a preclinical murine study using a simple UHPLC-MS/MS assay.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2026
Same author

Discovery of multitargeting single agents as a novel route to the potential treatment of neurodegenerative diseases.

Bioorganic & medicinal chemistry letters·2026
Same author

Pharmacodynamic determinants of mitochondrial one-carbon flux and serine hydroxymethyltransferase inhibition in human tumors.

Drug metabolism and disposition: the biological fate of chemicals·2025
Same author

Role of Mitochondrial and Cytosolic Folylpolyglutamate Synthetase in One-Carbon Metabolism and Antitumor Efficacy of Mitochondrial-Targeted Antifolates.

Molecular pharmacology·2024
Same author

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer.

Molecular cancer therapeutics·2024
Same author

Structural Characterization of 5-Substituted Pyrrolo[3,2-<i>d</i>]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.

Biochemistry·2024
Same journal

Selenium derivatives as cancer preventive agents.

Current medicinal chemistry. Anti-cancer agents·2005
Same journal

Lycopene: a review of its potential as an anticancer agent.

Current medicinal chemistry. Anti-cancer agents·2005
Same journal

Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.

Current medicinal chemistry. Anti-cancer agents·2005
Same journal

Current drug therapy for prostate cancer: an overview.

Current medicinal chemistry. Anti-cancer agents·2005
Same journal

Lanthanides as anticancer agents.

Current medicinal chemistry. Anti-cancer agents·2005
Same journal

Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy.

Current medicinal chemistry. Anti-cancer agents·2005
See all related articles

This perspective reviews antifolates, a class of chemotherapy drugs. It covers their historical development, current clinical use, and future potential in cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Antifolates are a critical class of anticancer agents.
  • Their mechanism involves interfering with folate metabolism, essential for DNA synthesis and cell replication.

Purpose of the Study:

  • To provide a concise overview of antifolates in chemotherapy.
  • To discuss historical, current, and future aspects of antifolate drug development and application.

Main Methods:

  • Literature review and synthesis of existing research on antifolates.
  • Discussion of both classical and nonclassical antifolate analogs.

Main Results:

  • Antifolates have a long history in cancer treatment.
  • Current research focuses on novel analogs and overcoming resistance mechanisms.

Related Experiment Videos

  • Future directions include targeted delivery and combination therapies.

    • Conclusions:

    • Antifolates remain vital in chemotherapy.
    • Continued research into novel antifolate agents promises improved cancer treatment strategies.