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Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands
Nilesh Shah1, Thomas S Scanlan
1Graduate Group in Biophysics, University of California--San Francisco, San Francisco, CA 94143-2280, USA.
Abstract:
A novel class of phenylpyrazole fused Wieland-Miescher ketone derivatives are high affinity, receptor specific, selective modulators of glucocorticoid receptor (GR) mediated transcription in vitro, dissociating transactivation, AP-1 repression, and NF-kappaB repression from each other.
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