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Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
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Suppression of female-specific murine Cyp2b9 gene expression by growth or glucocorticoid hormones

Tsutomu Sakuma1, Kaori Kitajima, Mie Nishiyama

  • 1Department of Toxicology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. tsakuma@ms.toyama-mpu.ac.jp

Biochemical and Biophysical Research Communications
|September 24, 2004
PubMed

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Dosage Compensation

In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Abnormal Proliferation

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