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Published on: January 20, 2015
Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells
Woei-Cherng Shyu1, Shinn-Zong Lin, Hui-I Yang
1Department of Neurology, Neuro-Medical Scientific Center, Tzu-Chi Buddhist General Hospital, Tzu-Chi University, Hualien, Taiwan.
Background:
Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists.
Methods And Results:
Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia.
Conclusions:
G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
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