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Updated: Jul 13, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
In situ catalyst improvement in the proline-mediated alpha-amination of aldehydes
Hiroshi Iwamura1, Suju P Mathew, Donna G Blackmond
1Department of Chemistry, Imperial College, London SW7 2AZ, UK.
Abstract:
Kinetic investigations show that the proline-mediated alpha-amination of aldehydes exhibits autoinductive rate behavior and amplification of product enantiomeric excess. Further experiments highlight the role of product, offering suggestions for the design of catalysts of improved efficiency for such transformations. The unusual characteristics exhibited by these reactions implicate amino acid catalysis in rationalizations of the origin of biological homochirality.
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