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Fenitrothion-induced changes in lipids of rats
Shalini Roy1, Sharmila Roy, C B Sharma
1Department of Biotechnology, IIT, Roorkee-247667, India. shalubas2000@yahoo.com
Biomedical Chromatography : BMC
|September 24, 2004
Summary
Fenitrothion exposure causes dose-dependent lipid accumulation and altered phospholipid ratios in rat organs. These changes in triacylglycerol and phospholipids may disrupt biological functions.
Area of Science:
- Toxicology
- Biochemistry
- Lipid Metabolism
Background:
- Pesticides like fenitrothion can impact physiological processes.
- Understanding organ-specific lipid alterations is crucial for assessing toxicity.
Purpose of the Study:
- To investigate the dose-dependent effects of fenitrothion on lipid profiles in rat organs.
- To quantify changes in phospholipids and neutral lipids following fenitrothion exposure.
Main Methods:
- Rats were administered fenitrothion, and lipid profiles were analyzed up to 48 hours.
- High-performance liquid chromatography (HPLC) and gas-liquid chromatography (GLC) were employed for quantitative analysis.
Main Results:
- Fenitrothion induced dose-dependent lipid accumulation in liver, kidney, and brain.
- Significant increases in triacylglycerol, phosphatidyl choline, phosphatidyl ethanolamine, and phosphatidyl glycerol were observed.
- A notable decrease in phosphatidyl serine concentration was detected in treated rats.
Conclusions:
- Fenitrothion exposure alters the balance of phospholipids and neutral lipids in rat organs.
- These lipid compositional changes may lead to organ malfunctioning and altered biological properties.
