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Magnesium decreases cardiac injury in patients undergoing coronary artery bypass surgery

Adem Grbolar Resatoglu1, Orhan Saim Demirturk, Nuran Yener

  • 1Cankaya Hospital, Ankara, Turkey. ademgrbolar@hotmail.com

Annals of Saudi Medicine
|September 25, 2004
PubMed

Insights

Magnesium supplementation in cardioplegia significantly reduced cardiac injury markers after coronary artery bypass surgery. This suggests magnesium enhances myocardial protection during cardiopulmonary bypass.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Pharmacology

Background:

  • Magnesium's calcium-channel blocking properties may offer cardioprotection during cardiopulmonary bypass.
  • Investigated magnesium's role in myocardial protection during coronary artery bypass grafting (CABG).

Purpose of the Study:

  • To assess the effects of magnesium added to cardioplegia on myocardial injury markers in patients undergoing CABG.

Main Methods:

  • Twenty patients were randomized into a control group (cardioplegia) and a study group (cardioplegia with magnesium).
  • Intermittent antegrade warm blood hyperkalemic cardioplegia was used for myocardial protection.
  • Measured extracellular substrates including cardiac troponin I, creatinine phosphokinase, and lactate dehydrogenase pre- and post-operatively.

Main Results:

  • The study group showed significantly lower post-operative levels of creatinine phosphokinase, creatinine phosphokinase-MB, lactate dehydrogenase, and c-reactive protein (P<0.001).
  • Cardiac troponin I levels were also significantly reduced in the magnesium group post-cardiopulmonary bypass (P<0.005).

Conclusions:

  • Adding magnesium to intermittent antegrade warm blood hyperkalemic cardioplegia lowers cardiac myocardial injury markers post-cardiopulmonary bypass.
  • This finding suggests a potential benefit of magnesium for myocardial protection in cardiac surgery.
Abstract

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