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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Delineating noncovalent interactions between the azinomycins and double-stranded DNA: importance of the naphthalene
Cyrille A S Landreau1, Rachel C LePla, Michael Shipman
1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K., School of Chemistry, University of St. Andrews, Purdie Building, St. Andrews, Fife KY16 9ST, UK.
Abstract:
[reaction: see text] Using a series of synthetic azinomycin analogues, it is shown that the efficiency of in vitro DNA interstrand cross-linking is markedly reduced when either the C-5' methyl group or both the C-5' methyl and C-3' methoxy groups are deleted from the naphthalene ring.
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