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Updated: Aug 22, 2026

Solid Phase 11C-Methylation, Purification and Formulation for the Production of PET Tracers
Published on: October 24, 2019
New aspects on the preparation of [11C]acetate--a simple and fast approach via distillation
Markus Mitterhauser1, Wolfgang Wadsak, Andreas Krcal
1Department of Nuclear Medicine, University of Vienna, AKH Wien, Waehringer Guertel 18-20, Vienna A1090, Austria. markus.mitterhauser@akh-wien.ac.at
Abstract:
[11C]Acetate, initially developed for nuclear cardiology has gained increased interest also for oncological problems. A conjoint problem of all preparation methods is the high sensitivity of the Grignard-precursor to moisture, demanding long cleaning and drying procedures of apparatus and reaction vials. Our rationale was to simplify and accelerate the preparation of [11C]acetate by the development of an inert, sterile and disposable system. The present publication deals with the remote-controlled preparation of [11C]acetate via distillation into a buffer ready to use.
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