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Synthesis of microfolicoumarin, a constituent of Cedrelopsis microfoliata
Marellapudi S Ramachandra1, Somepalli Venkateswarlu, Gottumukkala V Subbaraju
1Laila Impex R & D Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, India.
Abstract:
Microfolicoumarin (1), a prenylcoumarin from Cedrelopsis microfoliata, was synthesized from 2,4,5-trimethoxybenzaldehyde in five steps. 1 did not show significant antioxidative activity, but the key intermediates, esculetin (3) and 5-prenylesculetin (6), exhibited strong antioxidative activity in both the superoxide-radical and 1,1-diphenyl-2-picrylhydrazyl radical-scavenging models.
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