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Platelet function unaffected by ozonated autohaemotherapy in chronically haemodialysed patients
Leszek Tylicki1, Slawomir Lizakowski, Bogdan Biedunkiewicz
1Department of Nephrology Transplantology and Internal Medicine, Medical University of Gdansk, Poland. leszek.tylicki@amg.gda.pl
Summary
Ozonated autohaemotherapy (O3-AHT) did not affect platelet aggregation in patients with peripheral arterial disease undergoing hemodialysis. This study suggests O3-AHT is safe regarding platelet function in this patient group.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Oxidative Medicine
Background:
- Ozone therapy is controversial due to its oxidant properties.
- Reactive oxygen species can promote platelet aggregation, linked to atherosclerosis.
- Platelet function in hemodialysis patients with peripheral arterial disease receiving O3-AHT was investigated.
Purpose of the Study:
- To evaluate the effect of ozonated autohaemotherapy (O3-AHT) on platelet function.
- To assess potential risks associated with O3-AHT in hemodialysis patients with peripheral arterial disease.
Main Methods:
- A crossover study design was employed.
- Patients received nine sessions of autohaemotherapy with oxygen followed by nine sessions of O3-AHT.
- Platelet function was measured via spontaneous and agonist-induced aggregation (AIPA) using adenosine.
Main Results:
- No significant differences in spontaneous or agonist-induced platelet aggregation were observed between O3-AHT and oxygen control sessions.
- Platelet aggregation levels remained unchanged after the initial O3-AHT session compared to baseline.
Conclusions:
- Ozonated autohaemotherapy (O3-AHT) at 50 microg/ml with citrate anticoagulant does not induce platelet aggregation.
- The findings suggest O3-AHT is safe concerning platelet function in this patient cohort.