Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Distributed diffusion-clearance model for transient drug distribution within the skin.

Kosmas Kretsos1, Gerald B Kasting, Johannes M Nitsche

  • 1Department of Chemical and Biological Engineering, State University of New York, University at Buffalo, Furnas Hall, Buffalo, New York 14260-4200, USA.

Journal of Pharmaceutical Sciences
|September 25, 2004
PubMed
Summary

This study presents a new transient model for predicting molecular transport through skin, improving drug delivery and dermal exposure assessments. The model accurately characterizes salicylic acid

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does slowly reversible binding to keratin contribute to stratum corneum reservoir function?

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Are lateral lipid-phase diffusion coefficients pertinent to dermal absorption?

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Impact of solvent dry down, phase change, vehicle pH and slowly reversible keratin binding on skin penetration of cosmetic relevant compounds: II. Solids.

International journal of pharmaceutics·2024
Same author

Modeling the percutaneous absorption of solvent-deposited solids over a wide dose range: II. Weak electrolytes.

Journal of controlled release : official journal of the Controlled Release Society·2023
Same author

Solvent and Crystallization Effects on the Dermal Absorption of Hydrophilic and Lipophilic Compounds.

Journal of pharmaceutical sciences·2023
Same author

Transdermal and lateral effective diffusivities for drug transport in stratum corneum from a microscopic anisotropic diffusion model.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2023

Area of Science:

  • Pharmacokinetics and Dermal Absorption
  • Mathematical Modeling of Biological Systems
  • Drug Delivery and Toxicology

Background:

  • Accurate prediction of molecular transport through skin is crucial for drug development and risk assessment.
  • Existing models often oversimplify vascular clearance and the spatial distribution of blood vessels.
  • A comprehensive transient model is needed to better represent percutaneous absorption.

Purpose of the Study:

  • To develop and validate a comprehensive transient model for percutaneous absorption.
  • To incorporate volumetric dispersion and clearance coefficients reflecting vascular processes.
  • To predict subsurface drug concentrations in the skin.

Main Methods:

  • Formulation of a transient model for percutaneous absorption using volumetric dispersion and clearance coefficients.

Related Experiment Videos

  • Implementation of the model through analysis of in vivo experimental data for salicylic acid (SA) in rat skin.
  • Application of a whole-skin model variant including stratum corneum and viable epidermis.

    • Main Results:

    • Characterization of salicylic acid in rat dermis: dermal effective partition coefficient (K(de/pH7.4) ≈ 1), insignificant increase in dispersion by vascular processes (D(de) ≈ 8 x 10(-7) cm(2) s(-1)), and a vascular clearance rate coefficient (k(de) = 7 x 10(-4) s(-1)).
    • The model successfully predicted transient subsurface concentration levels.
    • Validated the model's ability to make realistic predictions for finite dose applications.

    Conclusions:

    • The developed transient model provides a more comprehensive approach to understanding percutaneous absorption.
    • The model accurately quantifies dermal transport parameters and vascular contributions.
    • This enhanced modeling capability supports improved topical drug development and dermal risk assessment.