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Familial cardiac myxoma
H M van Gelder1, D J O'Brien, E D Staples
1Division of Thoracic and Cardiovascular Surgery, University of Florida College of Medicine, Gainesville 32610.
The Annals of Thoracic Surgery
|March 1, 1992
Summary
Cardiac myxomas can occur sporadically or as part of familial or syndrome forms. Familial and syndrome myxomas present earlier, are more widespread, and recur more often than sporadic types.
Area of Science:
- Cardiology
- Genetics
- Pathology
Background:
- Cardiac myxomas are typically sporadic, isolated left atrial tumors in middle-aged women.
- Familial and syndrome forms of cardiac myxomas have been identified, differing from the common sporadic type.
Observation:
- Syndrome myxomas may manifest with pigmented skin lesions and neoplasms.
- Familial and syndrome myxomas often present at a younger age.
- These forms can exhibit unusual locations, multicentricity, and rare associated pathologies.
Findings:
- Familial and syndrome cardiac myxomas are distinguished by early onset, multifocal lesions, and unique pathological associations.
- A higher recurrence rate is characteristic of familial and syndrome myxoma forms.
- This report details two new cases, adding to the 15 previously documented families with cardiac myxomas.
Implications:
- Distinguishing between sporadic, familial, and syndrome myxomas is crucial for patient management and prognosis.
- Understanding these distinct forms aids in identifying at-risk individuals and families.
- Further research into the genetic and molecular underpinnings of familial and syndrome myxomas is warranted.