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Experimental renal embolization: preliminary results with polyacrylonitrile-based multiblock copolymers.
1Department of Radiology, University of California, Davis Medical Center, Sacramento 95817.
Journal of Vascular and Interventional Radiology : JVIR
|February 1, 1992
Summary
Polyacrylonitrile (PAN) preparations show promise as new therapeutic embolization agents. This study found PAN effective in causing renal infarcts in rabbits, suggesting potential for clinical use in embolization procedures.
Area of Science:
- Biomaterials Science
- Interventional Radiology
- Nephrology
Background:
- Polyacrylonitrile (PAN) is being explored for therapeutic embolization.
- Effective agents are needed for procedures like renal embolization.
Purpose of the Study:
- To evaluate the efficacy of liquid and solid polyacrylonitrile (PAN) formulations as renal embolization agents.
- To assess the potential of PAN in inducing renal infarction.
Main Methods:
- Three PAN preparations (two liquid, one solid particle form) were tested.
- Unilateral renal embolization was performed on 18 rabbits (n=6 per group).
- Angiographic and pathological assessments documented the outcomes.
Main Results:
- All embolized kidneys showed successful infarction across all three PAN preparations.
- Angiograms and pathological findings confirmed the effectiveness of PAN in inducing infarcts.
- No significant adverse events were detailed, but efficacy was demonstrated.
Conclusions:
- Polyacrylonitrile (PAN) demonstrates effectiveness as a renal embolization agent.
- PAN formulations, including liquid and solid forms, show potential for clinical application in renal embolization.
- Further research is warranted to explore PAN's therapeutic possibilities.