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Central conduction time in progressive supranuclear palsy.

A Pakalnis1, M E Drake, S Huber

  • 1Department of Neurology, Ohio State University Hospitals, Columbus.

Electromyography and Clinical Neurophysiology
|January 1, 1992
PubMed
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This study investigated brainstem auditory (BAEP) and somatosensory (SSEP) evoked potentials in progressive supranuclear palsy (PSP). Findings suggest SSEP abnormalities may indicate central demyelination and aid in differentiating PSP from Parkinsonian conditions.

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Neurophysiology

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disorder.
  • Pathological studies indicate brainstem demyelination in PSP.
  • Distinguishing PSP from other parkinsonian syndromes can be challenging.

Purpose of the Study:

  • To investigate brainstem auditory evoked potentials (BAEPs) and somatosensory evoked potentials (SSEPs) in patients with PSP.
  • To assess for evidence of central demyelination within the brainstem.
  • To evaluate the utility of evoked potentials in differentiating PSP from other parkinsonian disorders.

Main Methods:

  • Studied 8 patients diagnosed with progressive supranuclear palsy.
  • Recorded brainstem auditory evoked potentials (BAEPs).

Related Experiment Videos

  • Recorded brainstem somatosensory evoked potentials (SSEPs).

    • Main Results:

    • Observed minor alterations in BAEPs.
    • Frequently detected abnormal SSEPs in PSP patients.
    • Results suggest white matter involvement in the brainstem.

    Conclusions:

    • Evoked potentials, particularly SSEPs, show promise in detecting brainstem white matter abnormalities in PSP.
    • Evoked potential testing may serve as a valuable tool for differential diagnosis of PSP.
    • Further research can refine the role of evoked potentials in PSP diagnosis.