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Updated: Aug 21, 2026
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Preoperative mannan-binding lectin pathway and prognosis in colorectal cancer
Henriette Ytting1, Ib Jarle Christensen, Jens Christian Jensenius
1Department of Surgical Gastroenterology 435, Hvidovre University Hospital, Kettegard Allé 30, 2650 Hvidovre, Denmark. ytting@dadlnet.dk
Purpose:
Deficiency of the mannan-binding lectin (MBL) pathway of innate immunity is associated with increased susceptibility to infections. In patients with colorectal cancer (CRC), postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for CRC, and (2) the role of MBL in acute phase response compared to C-reactive protein (CRP).
Methods:
Preoperative MBL concentration, MBL-associated serine protease (MBL/MASP) activity and CRP were determined in serum from 611 patients and 150 healthy controls. The patients were observed for 8 years. Postoperative infections, recurrence and survival were recorded.
Results:
The MBL pathway components were increased in the patients compared with the healthy controls (p < 0.0001). Low MBL levels were predictive of pneumonia (p = 0.01), and pneumonia (n = 87) was associated with poor survival (p = 0.003; HR = 1.5; 95% CI, 1.1 to 1.9). MBL and MBL/MASP activity showed no correlation with CRP (Spearman's rho = 0.02; 95% CI, -0.06 to 0.10).
Conclusion:
Low preoperative MBL levels are predictive of pneumonia, which is associated with poorer survival. MBL concentration and MBL/MASP activity was not predictive of other postoperative infections or long-term prognosis, and showed no correlation with CRP.
