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Abnormalities in liver enzyme levels during Salmonella enteritidis enterocolitis
A González-Quintela1, J Campos, R Alende
1Department of Internal Medicine, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain. mearturo@usc.es
Revista Espanola De Enfermedades Digestivas
|September 29, 2004
Summary
Abnormal liver enzymes are common in adults with Salmonella enteritidis enterocolitis. These enzyme elevations are typically moderate and resolve on their own after the infection clears.
Area of Science:
- Gastroenterology
- Hepatology
- Infectious Diseases
Background:
- Salmonella enteritidis enterocolitis can affect various organs.
- Liver enzyme abnormalities are potential complications of infectious diseases.
Purpose of the Study:
- To determine the frequency of abnormal liver enzymes in adults with S. enteritidis enterocolitis.
- To identify factors associated with these abnormalities.
- To track changes in liver enzyme levels over time.
Main Methods:
- Retrospective review of 104 adult patients hospitalized with S. enteritidis enterocolitis.
- Analysis of liver enzyme levels (AST, ALT, GGT, alkaline phosphatase).
- Correlation with systemic inflammatory response, sepsis, and bacteremia data; follow-up in 16 patients.
Main Results:
- 35.7% of patients without pre-existing liver issues had abnormal AST, ALT, or GGT.
- Elevations were moderate and associated with fever.
- Liver enzyme levels normalized during convalescence post-discharge.
Conclusions:
- Abnormal liver enzyme levels are frequent in severe S. enteritidis enterocolitis.
- These abnormalities are generally moderate and self-limiting.