Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fascin protrusions in cell interactions.

Josephine C Adams1

  • 1Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. adamsj@ccf.org

Trends in Cardiovascular Medicine
|September 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The evolution of tenascins.

BMC ecology and evolution·2024
Same author

Thrombospondins: Conserved mediators and modulators of metazoan extracellular matrix.

International journal of experimental pathology·2024
Same author

Physiological Reports 10th anniversary year: Looking to the future.

Physiological reports·2024
Same author

Physiological Reports celebrates its first 10 years.

Physiological reports·2023
Same author

Physiological Reports begins a new manuscript category, the Methods article.

Physiological reports·2023
Same author

Molecular evolution of the Thrombospondin superfamily.

Seminars in cell & developmental biology·2023

Fascin-1 is a key actin-bundling protein essential for cell protrusions, which are vital for cell adhesion, interaction, and migration. This review explores fascin

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell protrusions are critical for cellular functions like environmental sensing and adhesion.
  • Two main types exist: finger-like and broad lamellipodial protrusions, both requiring cytoskeletal support.
  • Actin microfilaments form the structural basis for these protrusions.

Purpose of the Study:

  • To review the molecular and cellular properties and functions of fascin-1.
  • To discuss the role of fascin-1-based protrusions in the cardiovascular system.
  • To highlight areas for future research regarding fascin-1.

Main Methods:

  • Review of existing scientific literature on fascin-1 and cell protrusions.
  • Analysis of studies across various vertebrate and invertebrate cell types.

Related Experiment Videos

  • Focus on the structural role of actin-bundling proteins.

    • Main Results:

    • Fascin-1 is identified as a crucial actin-bundling protein across diverse cell protrusions.
    • Fascin-1 supports cell adhesion, cell interactions, and cell migration.
    • Specific roles of fascin-1 in cardiovascular health and disease are explored.

    Conclusions:

    • Fascin-1 is a universally important protein for the formation and function of cell protrusions.
    • Understanding fascin-1's role is key to comprehending cellular dynamics in various physiological and pathological contexts, particularly in the cardiovascular system.
    • Further investigation into fascin-1 is warranted for potential therapeutic applications.