Related Experiment Video
Updated: Aug 21, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
Published on: January 14, 2009
Mechanisms of pefloxacin-induced pain
M L Kukushkin1, S I Igonkina, T A Guskova
1Laboratory of Pathophysiology of Pain, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Abstract:
In electrophysiological and behavioral experiments on rats we studied the effects of pefloxacin, a member of fluoroquinolone family, on the nociceptive system. Intraperitoneal injection of pefloxacin (80 mg/kg) decreased the thresholds of nociceptive response to noxious stimulation in the hot-plate test. In addition, it decreased the threshold of the late component of nociceptive flexor reflex. Intrathecal application of pefloxacin in a dose of 20 microg provoked allodynia, while the higher dose of 400 microg induced behavioral pattern characteristic of central pain syndrome. It was hypothesized that pain induced by pefloxacin results from disturbances in GABAergic inhibition in the central subdivisions of the nociceptive system.
Related Concept Videos
Analgesia and Pain Management
Nociception
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Pain
Local Anesthetics: Adverse Effects
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Acute Inflammation III: Local and Systemic Effects
