Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction pathways linking polyamines to apoptosis.

C Pignatti1, B Tantini, C Stefanelli

  • 1Department of Biochemistry G. Moruzzi, University of Bologna, Bologna, Italy. carla.pignatti@unibo.it

Amino Acids
|September 29, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early antimicrobial regimen shapes gut microbiota and health trajectories in pigs: a longitudinal study from weaning to finishing.

Animal microbiome·2025
Same author

Social media and e-learning use among European exercise science students.

Health promotion international·2019
Same author

Speckle Tracking Echocardiography in Non-ST-Segment Elevation Acute Coronary Syndromes.

Current problems in cardiology·2019
Same author

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death.

Osteoarthritis and cartilage·2016
Same author

MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins.

Osteoarthritis and cartilage·2016
Same author

p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells.

Biochemical and biophysical research communications·2015
Same journal

The effects of glutamine supplementation on inflammatory and oxidative stress indices in chronic diseases: a systematic review.

Amino acids·2026
Same journal

Reprogramming parasitic signatures into anticancer peptide candidates: in silico discovery of Leishmania major-derived peptides.

Amino acids·2026
Same journal

Effects of taurine on skeletal muscle in senescence-accelerated mice and C2C12 myoblasts and myotubes.

Amino acids·2026
Same journal

Dual functions of thermospermine in plant growth and stress responses.

Amino acids·2026
Same journal

Zinc finger protein-associated gene signature serves as a potential predictor for prognosis and therapeutic response in lung adenocarcinoma.

Amino acids·2026
Same journal

LC-MS assay for quantifying ornithine decarboxylase activity in the biological matrix and cultured cells using stable isotope‑labeled ornithine.

Amino acids·2026
See all related articles

Polyamines are key regulators of cell growth and death, influencing proliferation or apoptosis based on cell type and signals. They impact multiple stages of the apoptotic cascade, including mitochondrial and pre-mitochondrial phases.

Area of Science:

  • Cell Biology
  • Biochemistry

Background:

  • Polyamines are essential multifunctional cellular components.
  • Traditionally viewed as mediators of cell growth and division.
  • Emerging evidence implicates polyamines in regulating cell death pathways.

Purpose of the Study:

  • To review the role of polyamines in signaling pathways related to apoptotic cell death.
  • To identify proposed molecular targets of polyamines within the apoptotic cascade.
  • To elucidate the dual role of polyamines in promoting either cell proliferation or cell death.

Main Methods:

  • Literature review of studies on polyamines and apoptosis.
  • Analysis of polyamine involvement in different phases of apoptosis (pre-mitochondrial, mitochondrial, post-mitochondrial).

Related Experiment Videos

  • Examination of polyamine interactions with signal transduction pathways and protein expression.

    • Main Results:

    • Polyamines act as bivalent regulators, influencing cell fate based on context.
    • Evidence suggests polyamines modulate mitochondrial cytochrome c release and caspase activation.
    • Polyamines are implicated in regulating the pre-mitochondrial phase, affecting upstream apoptotic signaling.

    Conclusions:

    • Polyamines play a critical role in the complex regulation of apoptosis.
    • They interact with signaling pathways to control cell death or growth.
    • Further research into polyamine-mediated cell death regulation is warranted.