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Role of ciprofloxacin in typhoid fever
M A Akhtar1, A Hussain, K A Karamat
1Division of Medicine, Army Medical College, Rawalpindi.
Abstract:
A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol. Eighty patients between 20-45 years with positive blood culture were included in the study. Seventy five percent patients treated with ciprofloxacin became afebrile within 72 hours while with chloramphenicol it took upto 120-144 hours for the same percentage of patients to become afebrile. Four patients resistant to chloramphenicol, cotrimoxazole and ampicillin/amoxycillin, also responded to ciprofloxacin. There were no significant adverse effects indicating that ciprofloxacin is safe and effective drug for resistant and nonresistant cases of typhoid fever.
Insights
Ciprofloxacin effectively treats typhoid fever, including resistant strains, with faster recovery times compared to chloramphenicol. This study confirms ciprofloxacin as a safe and effective option for typhoid fever management.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Typhoid fever remains a significant global health concern.
- Antibiotic resistance in Salmonella Typhi is a growing challenge.
- Chloramphenicol has been a traditional treatment but faces resistance issues.
Purpose of the Study:
- To evaluate the efficacy of ciprofloxacin in treating typhoid fever.
- To compare the effectiveness of ciprofloxacin against chloramphenicol.
- To assess the safety and tolerability of ciprofloxacin.
Main Methods:
- A study involving 80 patients diagnosed with typhoid fever (positive blood culture).
- Patients were treated with either ciprofloxacin or chloramphenicol.
- Clinical outcomes, including fever resolution time and adverse effects, were monitored.
Main Results:
- 75% of patients on ciprofloxacin became afebrile within 72 hours.
- 75% of patients on chloramphenicol required 120-144 hours to become afebrile.
- Ciprofloxacin demonstrated efficacy in four patients with multi-drug resistant typhoid fever.
- No significant adverse effects were reported for ciprofloxacin.
Conclusions:
- Ciprofloxacin is a safe and effective treatment for typhoid fever.
- Ciprofloxacin offers a faster resolution of fever compared to chloramphenicol.
- Ciprofloxacin is a viable option for both resistant and non-resistant typhoid fever cases.