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Updated: Jul 14, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
Published on: December 8, 2023
[Toxic shock syndrome in 3 children]
M van der Meulen1, E P M van Elzakker, L van Veen
1Afd. Kindergeneeskunde, Reinier de Graaf Gasthuis, Reinier de Graafweg 3-11, 2625 AD Delft.
Abstract:
A 16-year-old and a 10-year-old girl were admitted with general signs of illness, and respectively a green vaginal discharge and a panaritium. They recovered following antibiotic treatment and surgical relief of the panaritium. A 2-year-old boy became ill the morning after eating tainted cold meat; he died in the course of the following night. In all 3 patients Staphylococcus aureus was incubated with the toxic-shock-toxin-1-gene and/or the enterotoxin-A-gene. These 3 cases occurred within one year in a general hospital. TSS probably occurs more frequently than is generally assumed. Given that it is a life-threatening disease, rapid diagnosis is of major importance.
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