Related Experiment Video
Updated: Aug 21, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
Published on: April 28, 2020
[Toxic liver injuries]
1Klinik für Pharmakologie und Toxikologie, Universitätsspital Basel, Schweiz. kraehenbuehl@uhbs.ch
Abstract:
Drug induced hepatotoxicity is clinically important for several reasons. These forms of liver injury can mimic almost all other liver diseases, making it necessary to include them into the differential diagnosis in patients with unclear liver damage. The diagnosis must be made indirectly, by judging the temporal relationship with therapy and by exclusion of other liver diseases. Re-exposure is dangerous should be avoided. Knowledge of the most important risk factors is important for avoiding drug-induced liver injury. Since there is no specific therapy for most drug-induced liver injuries, early stopping of the administration of suspected drugs is very important.
Related Concept Videos
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Hepatic Encephalopathy
Drug Toxicity: Dose-Dependent Reactions
Drug Toxicity: Overview
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Prevention of Further Absorption of Poison

