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1Department of Microbiology and Molecular Genetics, The University of Vermont, Burlington, VT 05405, USA.
Structure (London, England : 1993)
|October 2, 2004
Abstract:
The crystal structures of DNA polymerase beta in complex with two different mispairs (A-C and T-C) reveal that the two bases stack partially, rather than engage in hydrogen bonding with each other (Krahn et al., this issue of Structure). The N-domain of the polymerase, which is closed when the correct nucleotide pairs with the template base, adopts a partially open conformation suboptimal for catalysis.
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