Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cryptochromes: tail-ored for distinct functions.

Carla B Green1

  • 1Department of Biology, Center for Biological Timing, 275 Gilmer Hall, University of Virginia, PO Box 400328, Charlottesville, Virginia 22904-4328, USA. cbg8b@virginia.edu

Current Biology : CB
|October 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary divergence of nocturnin led to redox regulation in mammalian orthologs.

Biochemistry and biophysics reports·2026
Same author

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.

Nature aging·2026
Same author

Circadian Alignment Through Time-Restricted Feeding: Implications for Health and Longevity.

Annual review of nutrition·2026
Same author

Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.

iScience·2026
Same author

Characterization of the enzymatic activity of the rhythmic human NADP(H) phosphatase, Nocturnin.

Archives of biochemistry and biophysics·2025
Same author

Loss of Nocturnin increases neuronal viability in oxidative stress conditions.

Frontiers in neuroscience·2025
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Cryptochromes are vital for circadian clocks in plants and animals. Their carboxy-terminal tails function distinctively across different species, revealing evolutionary divergence in biological timing mechanisms.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Chronobiology

Background:

  • Cryptochromes are essential blue-light receptors and components of circadian clocks.
  • These proteins play conserved roles in regulating daily rhythms in diverse organisms.
  • The carboxy-terminal (C-terminal) region of cryptochromes is known to be involved in signaling pathways.

Purpose of the Study:

  • To investigate the functional diversity of cryptochrome C-terminal tails.
  • To compare the mechanisms by which cryptochrome C-terminal regions are utilized in different biological systems.
  • To understand the evolutionary implications of variations in cryptochrome C-terminal tail function.

Main Methods:

  • Comparative analysis of cryptochrome sequences and structures.

Related Experiment Videos

  • Functional assays in model organisms (e.g., plants, animals).
  • Biochemical studies to elucidate protein-protein interactions.

    • Main Results:

    • Significant divergence in the C-terminal tail sequences and structures of cryptochromes across kingdoms.
    • Differential interaction partners identified for C-terminal tails in plants versus animals.
    • Functional studies demonstrate distinct roles of C-terminal tails in light signaling and clock output.

    Conclusions:

    • The C-terminal tail of cryptochromes is a key determinant of functional specificity.
    • Evolutionary pressures have led to distinct mechanisms for cryptochrome-mediated signaling in plants and animals.
    • Understanding these differences provides insights into the adaptability of circadian systems.