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Related Experiment Videos

Interhemispheric interaction between human dorsal premotor and contralateral primary motor cortex.

Hitoshi Mochizuki1, Ying-Zu Huang, John C Rothwell

  • 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK.

The Journal of Physiology
|October 2, 2004
PubMed
Summary

Transcranial magnetic stimulation (TMS) reveals distinct interhemispheric communication between the right dorsal premotor cortex (dPM) and left primary motor cortex (M1). This interaction differs from M1-to-M1 pathways and may involve specific connections crucial for bimanual coordination.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Brain Stimulation

Background:

  • Interhemispheric interactions are crucial for motor control.
  • The precise pathways between the dorsal premotor cortex (dPM) and primary motor cortex (M1) are not fully understood.
  • Transcranial magnetic stimulation (TMS) is a valuable tool for investigating cortical excitability and connectivity.

Purpose of the Study:

  • To investigate interhemispheric interactions between the right dPM and left M1 using TMS.
  • To compare these interactions with those between bilateral M1s.
  • To explore the role of these interactions in motor control and bimanual coordination.

Main Methods:

  • Paired-pulse TMS protocol applied to ten healthy subjects.
  • Conditioning stimulus over right dPM at 90% or 110% resting motor threshold (RMT).

Related Experiment Videos

  • Measuring motor-evoked potentials (MEPs) in the first dorsal interosseous (FDI) muscle following left M1 stimulation at various interstimulus intervals (ISIs).

    • Main Results:

    • Right dPM stimulation suppressed left M1-evoked MEPs, with maximum effect at 8-10 ms ISIs.
    • This inhibition differed from M1-to-M1 inhibition in threshold and modulation by voluntary contraction.
    • Conditioning right dPM reduced short-interval intracortical inhibition (SICI) in left M1, unlike conditioning right M1.

    Conclusions:

    • Right dPM influences left M1 excitability through distinct interhemispheric pathways.
    • These pathways differ from those between bilateral M1s.
    • The findings suggest the presence of commissural fibers between dPM and contralateral M1, potentially important for bimanual coordination.