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Updated: Aug 21, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
Cytolytic vaginosis: misdiagnosed as candidal vaginitis
Nilgun Cerikcioglu1, M Sinan Beksac
1Marmara University, School of Medicine, Department of Microbiology, Tibbiye Street, 34668, Haydarpasa Campus, Istanbul, Turkey. nilguncerik@yahoo.com
Objectives:
In this study, 210 women with vaginal discharge and other symptoms/signs of genital pathology suggestive of vulvovaginal candidiasis (VVC) were involved in order to distinguish true WC and cytolytic vaginosis (CV) cases.
Methods:
Fungal cultures, 10% potassium hydroxide (KOH) and Gram stained preparations and pH measurements were performed on the vaginal discharge material of each patient.
Results:
Fifteen patients (7.1%) were diagnosed with cytolytic vaginosis according to their clinical and microbiological findings, including abundant lactobacilli, fragmented epithelial cells and/or free nuclei due to cytolysis, seen in their discharge materials on microscopic examination, but no fungal growth.
Conclusions:
The results of this study may contribute to the reports in the literature indicating the importance of such disorders, which are generally misdiagnosed as candidiasis.
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