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Updated: Aug 21, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
[Activation of ERK1/2 and Elk1 in A549 cells induced by crocidolite]
Xinchao Wang1, Yiming Wu, Zhuowei Li
1School of Public Health, Zhengzhou University, Zhengzhou 450052, China.
Objective:
To investigate the role of extracellular signal-regulated kinase (ERK) 1/2 and Elk1 in pulmonary disease induced by crocidolite asbestos fiber.
Method:
Western blotting and Immunoprecipitation were used to detect the expression of phosphorylated ERK1/2 and Elk1 in human bronchial airway A549 cell line stimulated by crocidolite.
Results:
The expression of phosphorylated ERK1/2 and Elk1 were striking higher than those of the control, the differences were significant (P < 0.05).
Conclusion:
Phosphorylated ERK1/2 and Elk1 probably involved in the process of the diseases induced by crocidolite.
