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Phenylalanine hydroxylase deficiency in the peripheral lymphocytes from phenylketonuria
1Department of Dermatology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda, Tokyo 102, Japan.
Abstract:
A radiograph of the incorporation of 3H-phenylalanine and 3H-tyrosine into cultured lymphocytes in a phenylketonuria patient indicates phenylalanine hydroxylase deficiency in the peripheral lymphocytes. Cultured lymphocytes from the patient showed much less uptake of 3H-phenylalanine and a slightly higher incorporation of 3H-tyrosine than the control. It is possible that a lack of phenylalanine hydroxylase in the peripheral lymphocytes of PKU patients prevents oxidation of phenylalanine to tyrosine.
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