Brugada electrocardiographic pattern elicited by inadvertent flecainide overdose
Christopher J Hudson1, Tanya E Whitner, Michael J Rinaldi
1Department of Internal Medicine, P.A. Carolinas Medical Center, Charlotte, North Carolina 28232, USA.
Abstract:
In a 70-year-old man, without clinical suggestion of the hereditary form of the Brugada syndrome, severe flecainide overdose resulted in profound widening of the QRS complex and the development of ST-T abnormalities typical of the Brugada sign. Serial ECGs recorded over a 5-day period revealed a parallel pattern of dynamic intraventricular conduction defect and ST-segment elevation. Resolution of ST-segment elevation lagged behind resolution of the QRS widening by 16-20 hours. Despite the marked Brugada abnormality no arrhythmia occurred and the patient recovered without complications.
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