Related Experiment Video

Updated: Aug 21, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

CRT and CABG Improve Survival and Reduce Readmissions in Ischemic Heart Failure: A Systematic Review and

Tasneem Zanati Saeed1, Ahmed Adel Mohamed2, Mariam Hanna3

  • 1Faculty of Medicine, Assiut University, Assiut, Egypt.

Pacing and Clinical Electrophysiology : PACE
|August 20, 2026
PubMed

Insights

Adding cardiac resynchronization therapy (CRT) to coronary artery bypass grafting (CABG) may reduce heart failure readmissions and mortality in patients with ischemic cardiomyopathy. Further large-scale trials are needed to confirm these findings.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Medical Technology

Background:

  • Heart failure (HF) is a major cause of death and rehospitalization in patients with cardiomyopathy undergoing coronary artery bypass grafting (CABG).
  • Electromechanical dyssynchrony is a common issue in these patients.

Purpose of the Study:

  • To systematically evaluate the effectiveness of adding cardiac resynchronization therapy (CRT) to CABG compared to CABG alone.
  • To assess the impact of CRT on survival and rehospitalization rates in patients with ischemic cardiomyopathy and electromechanical dyssynchrony.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Web of Science, and Scopus.
  • Included were 3 studies (300 patients) comparing CABG with CRT versus CABG alone.
  • A meta-analysis of two studies (200 patients) was conducted.

Main Results:

  • Adding CRT during CABG significantly lowered the probability of heart failure readmission (RR = 0.25).
  • All-cause mortality was also reduced in the CRT group (RR = 0.44).
  • Consistent treatment effects were observed across randomized and observational studies.

Conclusions:

  • Perioperative CRT implantation during CABG may decrease heart failure rehospitalization and all-cause mortality.
  • Findings are considered hypothesis-generating due to limited study numbers and sample size.
  • Large-scale randomized trials are warranted for confirmation.
Abstract

Keywords:
cardiac resynchronization therapycoronary artery bypass graftingdyssynchronyheart failuresurvival

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