Related Experiment Videos
Concomitant vitiligo and psoriasis in a patient treated with interferon alfa-2a for chronic hepatitis B infection
Deniz Seçkin1, Ciçek Durusoy, Sedef Sahin
1Department of Dermatology, Başkent University Faculty of Medicine, Ankara, Turkey. deseckin@hotmail.com
Abstract:
Well-known cutaneous side effects of interferon (IFN)-alfa therapy include dry skin, pruritus, hair loss, and psoriasis. Presumably because of its potent immunomodulatory activity, the use of IFN-alfa has also led to the development of autoimmune diseases in susceptible individuals. Vitiligo, an autoimmune cutaneous disease, has been reported to occur during IFN-alfa therapy. We report a 10-year-old girl with chronic hepatitis B infection in whom IFN-alfa treatment induced de novo development of vitiligo and psoriasis. Neither skin condition improved after withdrawal of interferon treatment. Concomitant occurrence of vitiligo and psoriasis due to IFN-alfa has not been reported previously.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Leishmaniasis
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Hepatitis
Chronic Pancreatitis II: Collaborative Care
Assessment:
Candidiasis