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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Advances in Sepsis Treatment

Todd W Rice, Gordon R Bernard

    Current Infectious Disease Reports
    |October 6, 2004
    PubMed

    Insights

    New pharmacologic therapies targeting sepsis, including drotrecogin alfa (activated), show promise. Early goal-directed resuscitation and tight glycemic control are also discussed for severe sepsis and septic shock management.

    Area of Science:

    • Critical Care Medicine
    • Pharmacology
    • Intensive Care

    Background:

    • Sepsis treatment has historically lacked targeted therapies despite advances in critical care.
    • A complex interplay between coagulation and inflammation systems has spurred novel pharmacologic approaches for sepsis.

    Purpose of the Study:

    • To review innovative pharmacologic therapies for severe sepsis.
    • To discuss early goal-directed resuscitation and corticosteroid use in septic shock.
    • To evaluate glycemic control in critically ill patients.

    Main Methods:

    • Summary of clinical trials involving drotrecogin alfa (activated) (recombinant human activated protein C).
    • Discussion of early, goal-directed resuscitation guided by central venous oxygen saturations.
    • Review of corticosteroid use in septic shock and glycemic control in postoperative patients.

    Main Results:

    • Drotrecogin alfa (activated) is the only FDA-approved medicine for severe sepsis.
    • Early goal-directed resuscitation demonstrates beneficial effects.
    • Tight glycemic control shows benefits in postoperative critically ill patients.

    Conclusions:

    • Drotrecogin alfa (activated) represents a significant advancement in severe sepsis treatment.
    • Early resuscitation strategies and glycemic control are crucial in managing critically ill patients.
    • Further research is needed to extrapolate glycemic control data to medical patients.

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