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Related Experiment Videos

Methanol toxicity in a newborn.

Martin Belson1, Brent W Morgan

  • 1National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. zqp2@cdc.gov

Journal of Toxicology. Clinical Toxicology
|October 7, 2004
PubMed
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Maternal methanol exposure can cause fatal poisoning in newborns. This case highlights the severe risks of transplacental methanol toxicity in infants, even with medical intervention.

Area of Science:

  • Toxicology
  • Neonatal Medicine
  • Maternal-Fetal Medicine

Background:

  • Methanol poisoning during pregnancy is rare and poorly documented.
  • This case presents the first documented instance of methanol concentration in a human newborn due to maternal exposure.

Observation:

  • A 28-week pregnant woman presented with respiratory distress, metabolic acidosis, and fetal bradycardia.
  • Her son, delivered via C-section, required aggressive resuscitation and exhibited persistent acidosis.
  • Both mother and infant showed elevated methanol levels, with the infant's level at 61.6 mg/dL.

Findings:

  • The newborn developed a grade 4 intraventricular hemorrhage and died on day 4.
  • The mother also experienced persistent metabolic acidosis and died on day 10.

Related Experiment Videos

  • Transplacental transfer of methanol led to fatal neonatal toxicity.

    • Implications:

    • This case underscores the critical danger of methanol exposure to pregnant women.
    • It emphasizes the need for prompt diagnosis and management of methanol poisoning in pregnancy.
    • Highlights the potential for severe, fatal outcomes in neonates due to transplacental methanol toxicity.